Reconstructive bone surgery aims to regenerate the loss or resorption of bone through materials and techniques that allow to mimic and activate specific and fundamental reparative mechanisms such as osteogenesis, osteoinduction, and osteoconduction.
With general good health conditions, the bone displays an excellent healing capacity; therefore, in case of bone defects, it is sufficient to fill the void of the loss of substance with grafts or bone substitutes to provide the three-dimensional structure to sustain the regeneration process.
However, infection, e.g., osteomyelitis, is one of the major postoperative complications and evolves in complete bone disruption. Local delivery of antibiotics maximizes target tissue concentration and minimizes systemic toxicity risks. The use of bone substitutes exploited as antibiotic carriers is ideal to plan efficient and tailored bone regeneration strategies.
To help surgeons in this task, we tested SpherHA release capacity with the most common antibiotics; the results are available in the report below: